Targeting immune checkpoints in anti-neutrophil cytoplasmic antibodies associated vasculitis: the potential therapeutic targets in the future

Anti-neutrophil cytoplasmic autoantibodies (ANCA) associated vasculitis (AAV) is a necrotizing vasculitis mainly involving small blood vessels. It is demonstrated that T cells are important in the pathogenesis of AAV, including regulatory T cells (Treg) and helper T cells (Th), especially Th2, Th17,...

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Главные авторы:	Menglu Pan, Huanhuan Zhao, Ruimin Jin, Patrick S. C. Leung, Zongwen Shuai
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2023-04-01
Серии:	Frontiers in Immunology
Предметы:	antineutrophil cytoplasmic autoantibody associated vasculitis immune checkpoint co-stimulatory signal pathway co-inhibitory signal pathway T cells immunotherapy
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1156212/full
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