PARPs and PARP inhibitors: molecular mechanisms and clinical applications
Abstract Poly (ADP-ribose) polymerases (PARPs) are a diverse family of enzymes that regulate genome stability, cell death, and stress responses through ADP-ribosylation. Among them, PARP1, PARP2, and PARP3 are central to cellular DNA repair, while tankyrases, and their isoforms, contribute to telome...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Springer
2025-12-01
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| Edice: | Molecular Biomedicine |
| Témata: | |
| On-line přístup: | https://doi.org/10.1186/s43556-025-00385-1 |
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