NOTCH1 intracellular domain stabilization by MDM2 plays a major role in NSCLC response to platinum

Abstract Despite major advances in the clinical management of non-small cell lung carcinoma (NSCLC), most patients treated with first-line platinum-based chemotherapy combined with immune checkpoint inhibitors will relapse, which constitutes an unmet medical need. Here, we found that various DNA dam...

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Detalhes bibliográficos

Principais autores:	Sara Bernardo, Lisa Brunet, Quentin Dominique Thomas, David Bracquemond, Céline Bouclier, Marie Colomb, Maicol Mancini, Eric Fabbrizio, Alba Santos, Sylvia-Fenosoa Rasamizafy, Amina-Milissa Maacha, Anais Giry, Emilie Bousquet-Mur, Laura Papon, Marion Goussard, Christophe Fremin, Andrea Pasquier, María Rodríguez, Camille Travert, Jean-Louis Pujol, Laetitia K Linares, Lisa Heron-Milhavet, Alexandre Djiane, Irene Ferrer, Luis Paz-Ares, Xavier Quantin, Luis M Montuenga, Hélène Tourriere, Antonio Maraver
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2026-01-01
coleção:	EMBO Molecular Medicine
Assuntos:	NSCLC Platinum Chemotherapy Resistance MDM2 Notch
Acesso em linha:	https://doi.org/10.1038/s44321-025-00354-9
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