P450 CYP2C epoxygenase and CYP4A ω-hydroxylase mediate ciprofibrate-induced PPARα-dependent peroxisomal proliferation

Peroxisomal proliferators, such as ciprofibrate, are used extensively as effective hypolipidemic drugs. The effects of these compounds on lipid metabolism require ligand binding activation of the peroxisome proliferator-activated receptor (PPAR) α subtype of nuclear receptors and involve transcripti...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Arnaldo Gatica, Mauricio C. Aguilera, David Contador, Gloria Loyola, Claudio O. Pinto, Ludwig Amigo, Juan E. Tichauer, Silvana Zanlungo, Miguel Bronfman
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2007-04-01
Schriftenreihe:	Journal of Lipid Research
Schlagworte:	P450 monooxygenases ω-hydroxylated-eicosatrienoic acids peroxisome proliferator-activated receptor α
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S0022227520434455
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