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Antinociceptive potency of a fluorinated cyclopeptide Dmt-c[D-Lys-Phe-p-CF3-Phe-Asp]NH2

Opioid peptides and opiate drugs such as morphine, mediate their analgesic effects, but also undesired side effects, mostly through activation of the mu opioid receptor. However, delta- and kappa-opioid receptors can also contribute to the analgesic effects of opioids. Recent findings showed that si...

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Principais autores: Justyna Piekielna-Ciesielska, Adriano Mollica, Stefano Pieretti, Jakub Fichna, Agata Szymaszkiewicz, Marta Zielińska, Radzisław Kordek, Anna Janecka
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2018-01-01
coleção:Journal of Enzyme Inhibition and Medicinal Chemistry
Assuntos:
Blood–brain barrier permeability
hot-plate test
anti-nociceptive and anti-inflammatory activity
colitis induction
myeloperoxidase activity
Acesso em linha:http://dx.doi.org/10.1080/14756366.2018.1441839
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