TNFa and IL2 Encoding Oncolytic Adenovirus Activates Pathogen and Danger-Associated Immunological Signaling

In order to break tumor resistance towards traditional treatments, we investigate the response of tumor and immune cells to a novel, cytokine-armed oncolytic adenovirus: Ad5/3-d24-E2F-hTNFa-IRES-hIL2 (also known as TILT-123 and OAd.TNFa-IL2). There are several pattern recognition receptors (PRR) tha...

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Detalhes bibliográficos

Principais autores:	Camilla Heiniö, Riikka Havunen, Joao Santos, Klaas de Lint, Victor Cervera-Carrascon, Anna Kanerva, Akseli Hemminki
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2020-03-01
Colecção:	Cells
Assuntos:	aenovirus virotherapy immunotherapy aim2 oncolytic virus tilt-123 immunological cell death damp pamp
Acesso em linha:	https://www.mdpi.com/2073-4409/9/4/798
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