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Lipid Antigen Presentation by CD1b and CD1d in Lysosomal Storage Disease Patients

The lysosome has a key role in the presentation of lipid antigens by CD1 molecules. While defects in lipid antigen presentation and in invariant Natural Killer T (iNKT) cell response were detected in several mouse models of lysosomal storage diseases (LSD), the impact of lysosomal engorgement in hum...

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Principais autores: Catia S. Pereira, Begoña Pérez-Cabezas, Helena Ribeiro, M. Luz Maia, M. Teresa Cardoso, Ana F. Dias, Olga Azevedo, M. Fatima Ferreira, Paula Garcia, Esmeralda Rodrigues, Paulo Castro-Chaves, Esmeralda Martins, Patricio Aguiar, Mercè Pineda, Yasmina Amraoui, Simona Fecarotta, Elisa Leão-Teles, Shenglou Deng, Paul B. Savage, M. Fatima Macedo
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019-06-01
Serier:Frontiers in Immunology
Fag:
lipid antigen presentation
CD1b
CD1d
dendritic cells
monocytes
lysosomal storage diseases
Online adgang:https://www.frontiersin.org/article/10.3389/fimmu.2019.01264/full
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