The Impact of On-Target Resistance Mediated by EGFR-T790M or EGFR-C797S on EGFR Exon 20 Insertion Mutation Active Tyrosine Kinase Inhibitors

Introduction: Mechanisms of resistance to EGFR exon 20 insertion mutation active inhibitors have not been extensively studied in either robust preclinical models or patient-derived rebiopsy specimens. We sought to characterize on-target resistance mutations identified in EGFR exon 20 insertion-mutat...

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मुख्य लेखकों:	Ikei S. Kobayashi, MD, PhD, William Shaffer, MS, Hollis Viray, MD, Deepa Rangachari, MD, Paul A. VanderLaan, MD, PhD, Susumu S. Kobayashi, MD, PhD, Daniel B. Costa, MD, PhD
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Elsevier 2024-01-01
श्रृंखला:	JTO Clinical and Research Reports
विषय:	EGFR-T790M EGFR-C797S Mobocertinib Zipalertinib Furmonertinib Sunvozertinib
ऑनलाइन पहुंच:	http://www.sciencedirect.com/science/article/pii/S2666364323001571
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