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Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion

Summary: Amplified lysosome activity is a hallmark of pancreatic ductal adenocarcinoma (PDAC) orchestrated by oncogenic KRAS that mediates tumor growth and metastasis, though the mechanisms underlying this phenomenon remain unclear. Using comparative proteomics, we found that oncogenic KRAS signific...

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Principais autores: Omar L. Gutierrez-Ruiz, Katherine M. Johnson, Eugene W. Krueger, Roseanne E. Nooren, Nicole Cruz-Reyes, Carrie Jo Heppelmann, Tara L. Hogenson, Martin E. Fernandez-Zapico, Mark A. McNiven, Gina L. Razidlo
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-09-01
Serier:Cell Reports
Fag:
CP: Cancer
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124723010537
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