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Understanding the dosing-time-dependent antihypertensive effect of valsartan and aspirin through mathematical modeling

Chronopharmacology of arterial hypertension impacts the long-term cardiovascular risk of hypertensive subjects. Therefore, clinical and computational studies have proposed optimizing antihypertensive medications’ dosing time (Ta). However, the causes and mechanisms underlying the Ta-dependency antih...

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Autors principals: Javiera Cortés-Ríos, Maria Rodriguez-Fernandez
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2023-03-01
Col·lecció:Frontiers in Endocrinology
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Accés en línia:https://www.frontiersin.org/articles/10.3389/fendo.2023.1110459/full
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