Differences in expression rather than methylation at placenta-specific imprinted loci is associated with intrauterine growth restriction

Abstract Background Genome-wide studies have begun to link subtle variations in both allelic DNA methylation and parent-of-origin genetic effects with early development. Numerous reports have highlighted that the placenta plays a critical role in coordinating fetal growth, with many key functions re...

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Detalhes bibliográficos

Principais autores:	Ana Monteagudo-Sánchez, Marta Sánchez-Delgado, Jose Ramon Hernandez Mora, Nuria Tubío Santamaría, Eduard Gratacós, Manel Esteller, Miguel López de Heredia, Virgina Nunes, Cecile Choux, Patricia Fauque, Guiomar Perez de Nanclares, Lauren Anton, Michal A. Elovitz, Isabel Iglesias-Platas, David Monk
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2019-02-01
coleção:	Clinical Epigenetics
Assuntos:	Imprinting Placenta DNA methylation Epigenetics
Acesso em linha:	http://link.springer.com/article/10.1186/s13148-019-0630-4
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