Regulation of NMDA Receptor Signaling at Single Synapses by Human Anti-NMDA Receptor Antibodies

The NMDA receptor (NMDAR) subunit GluN1 is critical for receptor function and plays a pivotal role in synaptic plasticity. Mounting evidence has shown that pathogenic autoantibody targeting of the GluN1 subunit of NMDARs, as in anti-NMDAR encephalitis, leads to altered NMDAR trafficking and synaptic...

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Hlavní autoři:	Charles A. Dean, Sarah R. Metzbower, Scott K. Dessain, Thomas A. Blanpied, David R. Benavides
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-07-01
Edice:	Frontiers in Molecular Neuroscience
Témata:	autoimmune encephalitis calcium signaling synaptic NMDA receptor neurotransmission
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fnmol.2022.940005/full
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