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Intramuscular vaccination against SARS-CoV-2 transiently induces neutralizing IgG rather than IgA in the saliva

The mucosal immunity is crucial for restricting SARS-CoV-2 at its entry site. Intramuscularly applied vaccines against SARS-CoV-2 stimulate high levels of neutralizing Abs in serum, but the impact of these intramuscular vaccinations on features of mucosal immunity is less clear. Here, we analyzed ki...

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Principais autores: Stephan Winklmeier, Heike Rübsamen, Ceren Özdemir, Paul R. Wratil, Gaia Lupoli, Marcel Stern, Celine Schneider, Katharina Eisenhut, Samantha Ho, Hoi Kiu Wong, Damla Taskin, Marvin Petry, Michael Weigand, Peter Eichhorn, Bärbel U. Foesel, Simone Mader, Oliver T. Keppler, Tania Kümpfel, Edgar Meinl
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-02-01
Serier:Frontiers in Immunology
Fag:
viral neutralization
saliva
COVID
vaccination
IgG
IgA
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1330864/full
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