Copy-number variants and polygenic risk for intelligence confer risk for autism spectrum disorder irrespective of their effects on cognitive ability

IntroductionRare copy number variants (CNVs) and polygenic risk for intelligence (PRS-IQ) both confer susceptibility for autism spectrum disorder (ASD) but have opposing effects on cognitive ability. The field has struggled to disentangle the effects of these two classes of genomic variants on cogni...

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Principais autores:	Zoe Schmilovich, Vincent-Raphaël Bourque, Elise Douard, Guillaume Huguet, Cécile Poulain, Jay P. Ross, Paria Alipour, Charles-Étienne Castonguay, Nadine Younis, Martineau Jean-Louis, Zohra Saci, Zdenka Pausova, Tomas Paus, Gunter Schuman, David Porteous, Gail Davies, Paul Redmond, Sarah E. Harris, Ian J. Deary, Heather Whalley, Caroline Hayward, Patrick A. Dion, Sébastien Jacquemont, Guy A. Rouleau
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2024-05-01
coleção:	Frontiers in Psychiatry
Assuntos:	CNV (copy number variant) polygenic risk score (PRS) ASD autism spectrum disorders cognitive abilities intelligence quotient (IQ)
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1369767/full
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