A self-binding immune complex vaccine elicits strong neutralizing responses against herpes simplex virus in mice

IntroductionIt has been known for over half a century that mixing an antigen with its cognate antibody in an immune complex (IC) can enhance antigen immunogenicity. However, many ICs produce inconsistent immune responses, and the use of ICs in the development new vaccines has been limited despite th...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Andrew G. Diamos, Mary D. Pardhe, Melissa H. Bergeman, Aigerim S. Kamzina, Michelle P. DiPalma, Sara Aman, Artemio Chaves, Kenneth Lowe, Jacquelyn Kilbourne, Ian B. Hogue, Hugh S. Mason
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2023-05-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	herpes simplex virus (HSV) vaccine immune complex (IC) plant-made complement receptor c1q neutralizing antibodies
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1085911/full
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