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Focal Adhesion Kinase Drives Rho/ROCK and mTOR Signaling to Protect and Augment Aortic Dissections

Summary: Dysfunctional mechanosensing via focal adhesions (FAs) significantly contributes to thoracic aortic dissection in the β-aminopropionitrile mouse model by triggering FA kinase activation and subsequent Rho/ROCK and mTOR signaling pathways. The present findings indicate that these signaling p...

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Autori principali: Zhen Zhou, MD, Pujun Guan, PhD, Ripon Sarkar, PhD, Yang Yu, MD, Alexis Richard, PhD, Dar Weiss, PhD, Yuki Kawamura, PhD, Chen Zhang, MD, Yanming Li, PhD, Tomas Vaisar, PhD, Daniel R. Martin, PhD, L. Maximillian Buja, MD, Zhouxuan Li, PhD, Kartik Venkatachalam, PhD, Ying H. Shen, MD, PhD, Scott A. LeMaire, MD, Jay D. Humphrey, PhD, Dianna M. Milewicz, MD, PhD
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2025-09-01
Serie:JACC: Basic to Translational Science
Soggetti:
aortic dissection
extracellular matrix
focal adhesion kinase
lysyl oxidase
mTOR
Rho/ROCK
Accesso online:http://www.sciencedirect.com/science/article/pii/S2452302X25003067
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