NusG-Dependent RNA Polymerase Pausing and Tylosin-Dependent Ribosome Stalling Are Required for Tylosin Resistance by Inducing 23S rRNA Methylation in <named-content content-type="genus-species">Bacillus subtilis</named-content>

ABSTRACT Macrolide antibiotics bind to 23S rRNA within the peptide exit tunnel of the ribosome, causing the translating ribosome to stall when an appropriately positioned macrolide arrest motif is encountered in the nascent polypeptide. Tylosin is a macrolide antibiotic produced by Streptomyces frad...

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Bibliografische gegevens

Hoofdauteurs:	Helen Yakhnin, Alexander V. Yakhnin, Brandon L. Mouery, Zachary F. Mandell, Catherine Karbasiafshar, Mikhail Kashlev, Paul Babitzke
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology 2019-12-01
Reeks:	mBio
Onderwerpen:	NusG-dependent RNA polymerase pausing transcription attenuation antibiotic resistance rRNA methylation
Online toegang:	https://journals.asm.org/doi/10.1128/mBio.02665-19
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