Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice

The M5 muscarinic acetylcholine receptor (M5R) has been shown to play a crucial role in mediating acetylcholine-dependent dilation of cerebral blood vessels. We show that male M5R−/− mice displayed constitutive constriction of cerebral arteries using magnetic resonance angiography in vivo. Male M5R−...

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Detalhes bibliográficos

Principais autores:	Runa Araya, Takanori Noguchi, Munehiro Yuhki, Naohito Kitamura, Makoto Higuchi, Takaomi C. Saido, Kenjiro Seki, Shigeyoshi Itohara, Masako Kawano, Kentaro Tanemura, Akihiko Takashima, Kazuyuki Yamada, Yasushi Kondoh, Iwao Kanno, Jürgen Wess, Masahisa Yamada
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2006-11-01
coleção:	Neurobiology of Disease
Assuntos:	Cognition Cerebral blood flow Muscarinic acetylcholine receptor Neuronal atrophy
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996106001707
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