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Delayed miR-199a Administration After Myocardial Infarction Precludes Pro-Regenerative Effects

Summary: miR-199a carried by adeno-associated virus serotype 6 (AAV6) proved cardioreparative in a pig model when administered early after myocardial infarction (MI). To test whether the therapeutic efficacy of miR-199a is maintained when its administration is delayed, AAV6-miR-199a or a control AAV...

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Principais autores: Gia Burjanadze, MD, PhD, Nikoloz Gorgodze, MD, PhD, Giovanni Donato Aquaro, MD, Khatia Gabisonia, MD, PhD, Lucia Carlucci, VD, PhD, Manendra Pachauri, PhD, Federico Turreni, MD, Ilaria Secco, PhD, Fabio Bernini, MS, Lorena Zentilin, PhD, Mauro Giacca, MD, PhD, Fabio A. Recchia, MD, PhD
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-05-01
Serier:JACC: Basic to Translational Science
Fag:
gene therapy
heart
infarct
magnetic resonance
microRNA
Online adgang:http://www.sciencedirect.com/science/article/pii/S2452302X24004893
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