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The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends

Molecular chaperones from the Hsp70 family can break up protein aggregates, including amyloids. Here, the authors utilize microfluidic diffusional sizing to assess the mechanism of α-synuclein (αS) disaggregation by the Hsc70–DnaJB1–Apg2 system, and show that single αS molecules are removed directly...

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Furkejuvvon:
Váldodahkkit: Matthias M. Schneider, Saurabh Gautam, Therese W. Herling, Ewa Andrzejewska, Georg Krainer, Alyssa M. Miller, Victoria A. Trinkaus, Quentin A. E. Peter, Francesco Simone Ruggeri, Michele Vendruscolo, Andreas Bracher, Christopher M. Dobson, F. Ulrich Hartl, Tuomas P. J. Knowles
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Nature Portfolio 2021-10-01
Ráidu:Nature Communications
Liŋkkat:https://doi.org/10.1038/s41467-021-25966-w
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