FASN targeting by G28UCM impairs mitochondrial fatty acid synthesis and reveals a FASN–SDHB synthetic interaction

Metabolic reprogramming in cancer relies on lipid synthesis and mitochondrial function, yet how these processes, other than citrate flux and β-oxidation, intersect remains unclear. While inhibitors of lipogenic pathways have been developed as potential therapeutic agents in cancer therapy, their imp...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Nastasia Wilfinger-Lutz, Kristina M. Kuehrer, Maria J. Bueno, Michaela Schwaiger-Haber, Wang Wen Ann, Katrin Krejci, Ronald Mekis, Nicolle Gobbo Oliveira Erünlü, Anne Miller, Alexandra Junza, Siegfried Reipert, Michael Bergmann, Oscar Yanes, Arvand Haschemi, Gunda Koellensperger, Miguel Quintela-Fandino, Karin Nowikovsky
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2026-02-01
Schriftenreihe:	Pharmacological Research
Schlagworte:	FASN mtFAS SDHB LIAS Cancer G28UCM
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S1043661826000022
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