Phosphorylation of the Amyloid-Beta Peptide Inhibits Zinc-Dependent Aggregation, Prevents Na,K-ATPase Inhibition, and Reduces Cerebral Plaque Deposition

The triggers of late-onset sporadic Alzheimer’s disease (AD) are still poorly understood. Impairment of protein phosphorylation with age is well-known; however, the role of the phosphorylation in β-amyloid peptide (Aβ) is not studied sufficiently. Zinc-induced oligomerization of Aβ represents a pote...

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Principais autores:	Evgeny P. Barykin, Irina Y. Petrushanko, Sergey A. Kozin, Georgy B. Telegin, Alexander S. Chernov, Olga D. Lopina, Sergey P. Radko, Vladimir A. Mitkevich, Alexander A. Makarov
格式:	Artigo
語言:	Inglês
出版:	Frontiers Media S.A. 2018-08-01
叢編:	Frontiers in Molecular Neuroscience
主題:	Alzheimer’s disease β-amyloid Na+ K+-ATPase zinc protein phosphorylation
在線閱讀:	https://www.frontiersin.org/article/10.3389/fnmol.2018.00302/full
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