Rapamycin and abundant TCR stimulation are required for the generation of stable human induced regulatory T cells

Abstract Objectives Regulatory T cells (Tregs) are a vital sub‐population of CD4+ T cells with major roles in immune tolerance and homeostasis. Given such properties, the use of regulatory T cells for immunotherapies has been extensively investigated, with a focus on adoptive transfer of ex vivo exp...

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Hauptverfasser:	Juewan Kim, Christopher M Hope, Griffith B Perkins, Sebastian O Stead, Jacqueline C Scaffidi, Francis D Kette, Robert P Carroll, Simon C Barry, Patrick Toby Coates
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2020-01-01
Schriftenreihe:	Clinical & Translational Immunology
Schlagworte:	immunotherapy induced regulatory t cells rapamycin regulatory t cells TCR stimulation
Online-Zugang:	https://doi.org/10.1002/cti2.1223
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