Genomic, transcriptomic, and metabolomic profiles of hiPSC-derived dopamine neurons from clinically discordant brothers with identical PRKN deletions

Abstract We previously reported on two brothers who carry identical compound heterozygous PRKN mutations yet present with significantly different Parkinson’s Disease (PD) clinical phenotypes. Juvenile cases demonstrate that PD is not necessarily an aging-associated disease. Indeed, evidence for a de...

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Detalhes bibliográficos

Principais autores:	Holly N. Cukier, Hyunjin Kim, Anthony J. Griswold, Simona G. Codreanu, Lisa M. Prince, Stacy D. Sherrod, John A. McLean, Derek M. Dykxhoorn, Kevin C. Ess, Peter Hedera, Aaron B. Bowman, M. Diana Neely
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2022-06-01
coleção:	npj Parkinson's Disease
Acesso em linha:	https://doi.org/10.1038/s41531-022-00346-3
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