Rhodopsin targeted transcriptional silencing by DNA-binding

Transcription factors (TFs) operate by the combined activity of their DNA-binding domains (DBDs) and effector domains (EDs) enabling the coordination of gene expression on a genomic scale. Here we show that in vivo delivery of an engineered DNA-binding protein uncoupled from the repressor domain can...

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Autors principals:	Salvatore Botta, Elena Marrocco, Nicola de Prisco, Fabiola Curion, Mario Renda, Martina Sofia, Mariangela Lupo, Annamaria Carissimo, Maria Laura Bacci, Carlo Gesualdo, Settimio Rossi, Francesca Simonelli, Enrico Maria Surace
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2016-03-01
Col·lecció:	eLife
Matèries:	AAV rhodopsin transcription gene expression gene therapy neurodegeneration
Accés en línia:	https://elifesciences.org/articles/12242
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