Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1.

Host genetic variation modifying HIV-1 acquisition risk can inform development of HIV-1 prevention strategies. However, associations between rare or intermediate-frequency variants and HIV-1 acquisition are not well studied. We tested for the association between variation in genic regions and extrem...

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Hlavní autoři:	Romel D Mackelprang, Michael J Bamshad, Jessica X Chong, Xuanlin Hou, Kati J Buckingham, Kathryn Shively, Guy deBruyn, Nelly R Mugo, James I Mullins, M Juliana McElrath, Jared M Baeten, Connie Celum, Mary J Emond, Jairam R Lingappa, Partners in Prevention HSV/HIV Transmission Study and the Partners PrEP Study Teams
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2017-11-01
Edice:	PLoS Pathogens
On-line přístup:	https://doi.org/10.1371/journal.ppat.1006703
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