Is CD19-directed chimeric antigen receptor T cell therapy a smart strategy to combat central nervous system lymphoma?

Primary central nervous system lymphoma (PCNSL) is a rare form and aggressive type of diffuse large B-cell lymphoma (DLBCL) that occurs in both immunocompetent and immunocompromised adults. While adding rituximab to chemotherapeutic regimens resulted in dramatic improvement in both progression-free...

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Principais autores:	Kotaro Miyao, Hirofumi Yokota, R. Leo Sakemura
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2023-01-01
Serija:	Frontiers in Oncology
Teme:	CAR-T cell PCNSL CNS CNS penetration local administration
Online dostop:	https://www.frontiersin.org/articles/10.3389/fonc.2022.1082235/full
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