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Low-dose doxycycline prevents inflammatory bone resorption in rats

Matrix metalloproteinases (MMP) are considered to be key initiators of collagen degradation, thus contributing to bone resorption in inflammatory diseases. We determined whether subantimicrobial doses of doxycycline (DX) (<=10 mg kg-1 day-1), a known MMP inhibitor, could inhibit bone resorption in a...

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Principais autores: M.M. Bezerra, G.A.C. Brito, R.A. Ribeiro, F.A.C. Rocha
פורמט: Artigo
שפה:Inglês
יצא לאור: Associação Brasileira de Divulgação Científica 2002-05-01
סדרה:Brazilian Journal of Medical and Biological Research
נושאים:
Tetracyclines
Doxycycline
Metalloproteinases
Periodontitis
Osteoporosis
Bone resorption
Inflammation
גישה מקוונת:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000500015
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