Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor

The immune system distinguishes between self and foreign antigens. The kinetic proofreading (KPR) model proposes that T cells discriminate self from foreign ligands by the different ligand binding half-lives to the T cell receptor (TCR). It is challenging to test KPR as the available experimental sy...

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Главные авторы:	O Sascha Yousefi, Matthias Günther, Maximilian Hörner, Julia Chalupsky, Maximilian Wess, Simon M Brandl, Robert W Smith, Christian Fleck, Tim Kunkel, Matias D Zurbriggen, Thomas Höfer, Wilfried Weber, Wolfgang WA Schamel
Формат:	Artigo
Язык:	Inglês
Опубликовано:	eLife Sciences Publications Ltd 2019-04-01
Серии:	eLife
Предметы:	T cells ligand-receptor signaling dynamics optogenetics
Online-ссылка:	https://elifesciences.org/articles/42475
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