Integrative profiling of transcriptome and H3K27ac modification reveals changes associated with BCG-induced trained immunity in bovine immune cells

Abstract We previously demonstrated that Bacillus Calmette Guérin (BCG) vaccination induces trained immunity in bovine monocytes and gamma delta (γδ) T cells, enhancing IL-1β and IL-6 production. To define the underlying molecular mechanisms, we applied a multi-omic approach to circulating monocytes...

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Autors principals:	Beulah E. R. Samuel, Pengxin Yang, Christopher K. Tuggle, Jodi L. McGill
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-02-01
Col·lecció:	Scientific Reports
Matèries:	Trained immunity BCG vaccination Bovine Transcriptomics Epigenetics H3K27ac
Accés en línia:	https://doi.org/10.1038/s41598-026-39580-7
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