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The role of exosomal lncRNAs in acetaminophen-induced induced liver injury in SD rats

Background: Drug-induced liver injury (DILI) is a leading cause of drug development failures during clinical trials and post-market introduction. Current biomarkers, such as ALT and AST, lack the necessary specificity and sensitivity needed for accurate detection. Exosomes, which protect LncRNAs fro...

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Main Authors: Zixuan Yang, Lei Shi, Minhui Zheng, Minbo Hou, Mengdi Zhou, Naying Su, Hui Lang, Liyuan Zhao, Mengyun Gu, Naping Tang, Yan Chang
Format: Artigo
Language:Inglês
Published: KeAi Communications Co., Ltd. 2024-12-01
Series:Non-coding RNA Research
Subjects:
Exosome
LncRNA
RNA sequencing
PCR
DILI
Online Access:http://www.sciencedirect.com/science/article/pii/S2468054024000982
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