Aberrant expression of GTPase-activating protein ARAP1 triggers circular dorsal ruffles associated with malignancy in hepatocellular carcinoma Hep3B cells

Abstract Background Circular dorsal ruffles (CDRs) are large and rounded membrane ruffles that function as precursors of macropinocytosis. We recently reported that CDRs form in Hep3B hepatocellular carcinoma (HCC) cells, but not in Huh7 and HepG2 HCC cells or LO2 cells, suggesting that an unknown m...

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Detalhes bibliográficos

Principais autores:	Xiaowei Sun, Yanan Li, Yuxin He, Longjiao Cheng, Li Wang, Jinzi Wei, Jianan Chen, Linxuan Du, Zhongyang Shen, Yan Xie, Adam C. Midgley, Wentao Jiang, Sei Yoshida
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-02-01
Colecção:	Cell Communication and Signaling
Assuntos:	Circular dorsal ruffles Macropinocytosis ARAP1 Hepatocellular carcinoma
Acesso em linha:	https://doi.org/10.1186/s12964-025-02084-4
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