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Foot-and-Mouth Disease Virus 3C Protease Antagonizes Interferon Signaling and C142T Substitution Attenuates the FMD Virus

3C protease (3Cpro), a chymotrypsin-like cysteine protease encoded by the foot-and-mouth disease virus (FMDV), plays an essential role in processing the FMDV P1 polyprotein into individual viral capsid proteins in FMDV replication. Previously, it has been shown that 3Cpro is involved in the blockage...

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Principais autores: Pathum Ekanayaka, Sung Ho Shin, Prasanna Weeratunga, Hyuncheol Lee, Tae-Hwan Kim, Kiramage Chathuranga, Ashan Subasinghe, Jong-Hyeon Park, Jong-Soo Lee
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-11-01
coleção:Frontiers in Microbiology
Assuntos:
FMDV 3Cpro
RIG-I
MDA5
3Cpro C142T substitution
attenuated virus
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fmicb.2021.737031/full
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