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BCAA metabolism in pancreatic cancer affects lipid balance by regulating fatty acid import into mitochondria

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) has been associated with the host dysmetabolism of branched-chain amino acids (BCAAs), however, the implications for the role of BCAA metabolism in PDAC development or progression are not clear. The mitochondrial catabolism of valine, leuci...

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Main Authors: Klára Gotvaldová, Jitka Špačková, Jiří Novotný, Kamila Baslarová, Petr Ježek, Lenka Rossmeislová, Jan Gojda, Katarína Smolková
Format: Artigo
Language:Inglês
Published: BMC 2024-03-01
Series:Cancer & Metabolism
Subjects:
BCAA metabolism
Pancreatic cancer
Mitochondria
Triglycerides
Lipid droplets
Fatty acid/Transport
Online Access:https://doi.org/10.1186/s40170-024-00335-5
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