Synthesis and Evaluation of [¹⁸F]FEtLos and [¹⁸F]AMBF₃Los as Novel ¹⁸F-Labelled Losartan Derivatives for Molecular Imaging of Angiotensin II Type 1 Receptors

Losartan is widely used in clinics to treat cardiovascular related diseases by selectively blocking the angiotensin II type 1 receptors (AT₁Rs), which regulate the renin-angiotensin system (RAS). Therefore, monitoring the physiological and pathological biodistribution of AT₁R u...

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Auteurs principaux:	Martha Sahylí Ortega Pijeira, Paulo Sérgio Gonçalves Nunes, Sofia Nascimento dos Santos, Zhengxing Zhang, Arian Pérez Nario, Efrain Araujo Perini, Walter Miguel Turato, Zalua Rodríguez Riera, Roger Chammas, Philip H. Elsinga, Kuo-Shyan Lin, Ivone Carvalho, Emerson Soares Bernardes
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2020-04-01
Collection:	Molecules
Sujets:	fluoroethyl-losartan [<sup>18</sup>F]FEtLos ammoniomethyltrifluoroborate-losartan [<sup>18</sup>F]AMBF<sub>3</sub>Los angiotensin II type 1 receptors [<sup>18</sup>F]Fluoroethylation
Accès en ligne:	https://www.mdpi.com/1420-3049/25/8/1872
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