Stiffness-dependent alveolar type II cell senescence in idiopathic pulmonary fibrosis

Abstract Background IPF is characterized by the fibrotic response involving abnormally activated ATII cells. A stiffened matrix exerts extrinsic microenvironment-derived forces, leading to mechanical stress and ATII cell dysfunction. However, these mechanisms remain largely unknown. Methods ATII cel...

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Principais autores:	Chih-Ru Lin, Khanutsanan Woranam, Hassan Hayek, Jonathan Jeger, Loukmane Karim, Beata Kosmider, Rafal Kaminski, Christopher W. Schultz, Sudhir Bolla, Nathaniel Marchetti, Gerard J. Criner, Karim Bahmed
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2026-04-01
Series:	Cell Communication and Signaling
Assuntos:	IPF ATII cells DNA damage DNA repair Mechanical stress
Acceso en liña:	https://doi.org/10.1186/s12964-026-02881-5
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