Advances in Ommaya reservoir–based intrathecal therapy for leptomeningeal metastasis from non–small cell lung cancer: a systematic review

BackgroundLeptomeningeal metastasis (LM) from non–small cell lung cancer (NSCLC) is a devastating complication associated with a poor prognosis, with historical median overall survival (OS) of approximately 3–6 months. Limited penetration of systemic therapies across the blood–brain and blood–cerebr...

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Autors principals:	Cai Jiang, Yongzhi Zhao, Daohui Chen, Xiaofeng Yuan
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-05-01
Col·lecció:	Frontiers in Oncology
Matèries:	complications intrathecal chemotherapy leptomeningeal metastasis non–small cell lung cancer Ommaya reservoir targeted therapy
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1746953/full
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