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Post-translational activation of the C-terminus of polypeptides for the synthesis of peptide thioesters and peptide thioester surrogates

Semisynthesis using recombinant polypeptides is a powerful approach for the synthesis of proteins having a variety of modifications. Peptide thioesters, of which the peptide C-terminus is activated by a thioester, are utilized for coupling peptide building blocks. Biological methods employing intein...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Yanbo Liu, Yasuhiro Kajihara, Ryo Okamoto
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Frontiers Media S.A. 2024-07-01
Rangatū:Frontiers in Chemistry
Ngā marau:
Urunga tuihono:https://www.frontiersin.org/articles/10.3389/fchem.2024.1424953/full
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