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ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition

Abstract Hyalectan cleavage may play an important role in extracellular matrix remodeling. However, the proteolytic enzyme responsible for hyalectan degradation for fetal membrane rupture at parturition remains unknown. Here, we reveal that versican (VCAN) is the major hyalectan in the amnion, where...

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Главные авторы: Meng-Die Li, Jiang-Wen Lu, Fan Zhang, Wen-Jia Lei, Fan Pan, Yi-Kai Lin, Li-Jun Ling, Leslie Myatt, Wang-Sheng Wang, Kang Sun
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Portfolio 2024-03-01
Серии:Communications Biology
Online-ссылка:https://doi.org/10.1038/s42003-024-06007-w
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