Negative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2.

Wnt signalling is a key pathway controlling bone formation in mice and humans. One of the regulators of this pathway is Dkk1, which antagonizes Wnt signalling through the formation of a ternary complex with the transmembrane receptors Krm1/2 and Lrp5/6, thereby blocking the induction of Wnt signalli...

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Bibliografiske detaljer

Principais autores:	Jochen Schulze, Sebastian Seitz, Hiroaki Saito, Michael Schneebauer, Robert P Marshall, Anke Baranowsky, Bjoern Busse, Arndt F Schilling, Felix W Friedrich, Joachim Albers, Alexander S Spiro, Jozef Zustin, Thomas Streichert, Kristina Ellwanger, Christof Niehrs, Michael Amling, Roland Baron, Thorsten Schinke
Format:	Artigo
Sprog:	Inglês
Udgivet:	Public Library of Science (PLoS) 2010-04-01
Serier:	PLoS ONE
Online adgang:	https://doi.org/10.1371/journal.pone.0010309
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