Impaired muscle morphology in a Drosophila model of myosin storage myopathy was suppressed by overexpression of an E3 ubiquitin ligase

Myosin is vital for body movement and heart contractility. Mutations in MYH7, encoding slow/β-cardiac myosin heavy chain, are an important cause of hypertrophic and dilated cardiomyopathy, as well as skeletal muscle disease. A dominant missense mutation (R1845W) in MYH7 has been reported in several...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Martin Dahl-Halvarsson, Montse Olive, Malgorzata Pokrzywa, Michaela Norum, Katarina Ejeskär, Homa Tajsharghi
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	The Company of Biologists 2020-12-01
Schriftenreihe:	Disease Models & Mechanisms
Schlagworte:	slow/β-cardiac myosin heavy chain myh7 myosin storage myopathy drosophila model ubiquitin proteasome system e3 ubiquitin ligase potential therapeutic approach
Online-Zugang:	http://dmm.biologists.org/content/13/12/dmm047886
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