Engineered lipid hybrid nanoparticles for targeted delivery of SH2 superbinder and breast cancer therapy

Abstract SH2 Superbinder (SH2S) is an engineered polypeptide tool derived from the SH2 domain. It exhibits significantly enhanced binding capacity for tyrosine-phosphorylated proteins to treat various cancers. However, its clinical application is limited by poor serum stability and insufficient tumo...

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Autors principals:	Yuhe Zhu, Yazhou Sang, Linna Du, Fei Wang, Jisheng Zhang, Jianchang Luo, Caidi He, Jiawang Lang, Songwei Tan, Xuan Cao
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-03-01
Col·lecció:	Journal of Nanobiotechnology
Matèries:	SH2 Superbinder Breast cancer Protein delivery Poly (β-amino ester) Nanoparticles
Accés en línia:	https://doi.org/10.1186/s12951-026-04249-w
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