Increased Rab1a accelerates osteoarthritis by inhibiting autophagy via activation of the mTORC1-S6K pathway

Introduction: Cartilage degradation is a critical alteration in the progression of osteoarthritis (OA) due to the disorder of chondrocyte metabolic homeostasis. Autophagy plays an important role in maintaining intracellular homeostasis. Recent investigations have increasingly underscored the importa...

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Detalhes bibliográficos

Principais autores:	Ze Chen, Mingze Tang, Zewei Wu, Yongcong Lin, Cuixi Wu, Hong Huang, Jianmao Chen, Zhaohua Zhu, Yongming Liu, Súan Tang, Changhai Ding, Weiyu Han
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-09-01
coleção:	Journal of Advanced Research
Assuntos:	Osteoarthritis Rab1a mTORC1 Autophagy Apoptosis
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2090123224005010
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