Single-molecule analysis of the entire perfringolysin O pore formation pathway
The cholesterol-dependent cytolysin perfringolysin O (PFO) is secreted by Clostridium perfringens as a bacterial virulence factor able to form giant ring-shaped pores that perforate and ultimately lyse mammalian cell membranes. To resolve the kinetics of all steps in the assembly pathway, we have us...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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eLife Sciences Publications Ltd
2022-08-01
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| Schriftenreihe: | eLife |
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| Online-Zugang: | https://elifesciences.org/articles/74901 |
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