Pol θ-mediated end-joining uses microhomologies containing mismatches
Abstract DNA polymerase theta (Pol θ) initiates repair of DNA double-strand breaks by pairing single strands at short “microhomologies”. It is important to understand microhomology selection, as some cancer cells rely on Pol θ for survival. Here, we investigate end-joining by purified human Pol θ, e...
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| Principais autores: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Portfolio
2025-07-01
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| Serier: | Nature Communications |
| Online adgang: | https://doi.org/10.1038/s41467-025-61258-3 |
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