Targeting RAB7 in human B lymphoma by a small molecule inhibitor arrests tumor cell growth

RAB7, encoded by RAB7A in humans and Rab7 in mice, is a small GTPase that catalyzes endosome maturation. It mediates NF-κB activation through the assembly of intracellular membrane signalosomes in stimulated normal B cells and plays a B cell-intrinsic role in the antibody response in mice. Here we s...

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Hlavní autoři:	Maria Fernandez, Rui Wang, Jingwei Wang, Shuai Wu, Kenneth Holder, Alia Nazarullah, Ricardo C. T. Aguiar, Zijun Y. Xu-Monette, Ken H. Young, Hui Yan, Zhenming Xu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-09-01
Edice:	Frontiers in Oncology
Témata:	B cell lymphoma Burkitt lymphoma CID1067700 diffuse large B-cell lymphoma FX1 MβCD
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1616519/full
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