Reduced cortical cholinergic innervation measured using [18F]-FEOBV PET imaging correlates with cognitive decline in mild cognitive impairment

Dysfunction of the cholinergic basal forebrain (BF) neurotransmitter system, including cholinergic axon denervation of the cortex, plays an important role in cognitive decline and dementia. A validated method to directly quantify cortical cholinergic terminal integrity enables exploration of the inv...

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Auteurs principaux:	Ying Xia, Eamonn Eeles, Jurgen Fripp, Donna Pinsker, Paul Thomas, Melissa Latter, Vincent Doré, Amir Fazlollahi, Pierrick Bourgeat, Victor L. Villemagne, Elizabeth J. Coulson, Stephen Rose
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2022-01-01
Collection:	NeuroImage: Clinical
Sujets:	Basal forebrain Cholinergic system FEOBV Mild cognitive impairment PET imaging MRI
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2213158222000572
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