Inhibition of intrahepatic monocyte recruitment by Cenicriviroc and extracellular matrix degradation by MMP1 synergistically attenuate liver inflammation and fibrogenesis in vivo

Abstract The chemokine (CCL)-chemokine receptor (CCR2) interaction, importantly CCL2-CCR2, involved in the intrahepatic recruitment of monocytes upon liver injury promotes liver fibrosis. CCL2-CCR2 antagonism using Cenicriviroc (CVC) showed promising results in several preclinical studies. Unfortuna...

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主要な著者:	Eline Geervliet, Esmee Karkdijk, Ruchi Bansal
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2024-07-01
シリーズ:	Scientific Reports
主題:	Liver inflammation Liver fibrosis Monocyte recruitment Matrix metalloproteinase 1 CCR2/CCR5 antagonist
オンライン･アクセス:	https://doi.org/10.1038/s41598-024-67926-6
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