Exogenous adenosine counteracts tigecycline resistance in tet(X3)-harboring Escherichia coli

ABSTRACT The rapid spread of antibiotic resistance poses a global health crisis. Tigecycline is a last-resort antibiotic, but the recent emergence of the plasmid-borne tet(X3) gene conferring high-level tigecycline resistance is deeply concerning. Here, we report a metabolomics-guided approach to ov...

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Autori principali:	Jing Sun, Yiming Liu, Jiashen Chang, Ying Liu, Luqi Li, Ran Jiang, Yihan Luo, Shuo Yang, Mei Yang, Xinglong Wang, Juan Wang, Xi Xia, Kangkang Guo, Zengqi Yang, Dongyang Ye
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2025-08-01
Serie:	Microbiology Spectrum
Soggetti:	tet(X3) tigecycline adenosine antimicrobial resistance metabolomics
Accesso online:	https://journals.asm.org/doi/10.1128/spectrum.02382-24
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