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Pharmacology of Recombinant Adeno-associated Virus Production

Recombinant adeno-associated viral (rAAV) vectors have been used in more than 150 clinical trials with a good safety profile and significant clinical benefit in many genetic diseases. In addition, due to their ability to infect non-dividing and dividing cells and to serve as efficient substrate for...

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Principais autores: Magalie Penaud-Budloo, Achille François, Nathalie Clément, Eduard Ayuso
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018-03-01
Serier:Molecular Therapy: Methods & Clinical Development
Fag:
gene therapy
viral vectors
AAV
manufacturing
quality controls
impurities
Online adgang:http://www.sciencedirect.com/science/article/pii/S2329050118300032
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